One hundred years ago, Frederick Banting, MD had an idea in the middle of the night that culminated in the discovery of insulin, a ‘cure’ for certain death in patients with Type 1 diabetes. In this lecture Professor Patricia Brubaker will trace the origins of this discovery, covering not only the science and the individuals involved in this ground-breaking discovery, but also the process that led to the commercialization of insulin, enabling worldwide access to this lifesaving treatment.